GROLICAL™-DN | Bone/Cartilage Reinvent supplement

grolical-dn

DRUG ACKNOWLEDGEMENT OF GROLICAL™-DN

 

 Issued for Doctor’s convenience

To be used by Hospital, Laboratory & Registered Medical Practitioner

COMPOSITION >>>

Each tablet contains :-

Glucosamine sulfate———————–750mg

Diacerein————————————-50mg

Methylsulfonylmethane——————-250mg

 

GROLICAL™-DN: Glucosamine 750mg + Diacerein 50mg + Methylsulfonylmethane 250mg Tablet

GROLICAL™-DN: Glucosamine 750mg + Diacerein 50mg + Methylsulfonylmethane 250mg Tablet

 

PHARMACOKINETICS FACTS & ETHICS >>>

Glucosamine :

Glucosamine is marketed to support the structure and function of joints and the marketing is targeted to people suffering from osteoarthritis. Commonly sold forms of glucosamine are glucosamine sulfate, glucosamine hydrochloride, and N-acetylglucosamine. Glucosamine is often sold in combination with other supplements such as chondroitin sulfate and methylsulfonylmethane. Of the three commonly available forms of glucosamine, only glucosamine sulfate is given a “likely effective” rating for treating osteoarthritis.

Glucosamine, along with commonly used chondroitin, should not be used to treat patients who have symptomatic osteoarthritis of the knee as evidence shows that these treatments fail to provide relief for that condition.

In the US it is one of the most common non-vitamin, non-mineral, dietary supplements used by adults.

 

Diacerein :

Diacerein works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of cartilage that play a role in the development of symptoms of degenerative joint diseases such as osteoarthritis. Due to its specific mode of action, which does not involve the inhibition of prostaglandin synthesis, diacerein has been shown to have anti-osteoarthritis and cartilage stimulating properties in vitro and animal models. Due to its excellent gastro-intestinal tolerance, a combination therapy with an analgesic or a NSAID may be recommended during the first 2-4 weeks of treatment.

 

Methylsulfonylmethane (MSM) :

MSM is used as a dietary supplement with a variety of claims, often in combination with glucosamine and/or chondroitin for helping to treat or prevent osteoarthritis. According to one review, “The benefits claimed [for MSM] far exceed the number of scientific studies. It is hard to build a strong case for its use other than for treating arthritis problems.”

Moreover, in cases involving topical therapeutics, the role of MSM as an active agent, per se, versus its having a role in promoting skin permeation (in manner, akin to its solvent relative DMSO) must be characterized/controlled.  Some researchers have suggested that MSM has anti-inflammatory effects. The spectrum of biological effects of dimethyl sulfoxide (DMSO) and MSM differ, but those of DMSO may be mediated, at least in part, by MSM.

Herschler’s patent documents, and much of the alternative medical literature supporting MSM use, claim that “the average diet is deficient in methylsulfonylmethane because it is readily lost during conventional food processing, such as frying, dehydrating, dilution with synthetic fillers and other poorly nutritional additives, cooking, radiation or pasteurizing, and long-term storage”.

 

DOSAGE >>>  1 Tablet daily with Breakfast or As directed by Physician

 


Source : Wikipedia (Glucosamine / Diacerein / MSM)


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